The Dow and the S&P 500 closed in the green, but the Nasdaq finished in the red.
Shares of DowDuPont jumped after issuing preliminary third-quarter results.
Honeywell shares close higher after reporting better-than-expected sales.
The Dow, the Nasdaq and the S&P 500 all reached new record highs even though drug stocks were under pressure following comments by President Trump.
Even though shares of Proctor & Gamble fell, the Dow Jones Industrial Average reached another record high.
Casino stocks were in focus for a second day following the mass shooting in Las Vegas on Sunday.
Carnival shares jump after beating quarterly estimates but Adidas stock slumped following an investigation into a NCAA Bribery Scandal.
The S&P 500 added 0.08%, and the Nasdaq gained 0.06%. The Dow Jones Industrial Average remained lower, though, falling 0.07%.
U.S. indices closed mixed after the Federal Reserve keeps federal funds rates unchanged and prepares to reduce the balance sheet.
Both the Dow and the S&P 500 closed at record highs, while the Nasdaq also closed in the green.